Systems Bio
Trajectory Analysis
Terminal cells arise from progenitor cells through a series of tightly regulated differentiation steps, where gene expression programs are sequentially activated or repressed to drive cells toward their final specialized states. Disruptions in these regulatory mechanisms can lead to abnormal differentiation, resulting in pathological conditions such as cancer, developmental disorders, and degenerative diseases. Understanding the molecular mechanisms governing cell fate decisions is crucial for identifying key drivers of normal and aberrant differentiation.
By comparing cell differentiation trajectories between healthy and diseased states, researchers can uncover critical deviations that contribute to disease progression. Identifying these alterations can provide valuable insights into potential intervention points for therapeutic development. Systems Bio enables you to reconstruct and analyze cell differentiation pathways using genomic sequencing data, including single-cell RNA sequencing and epigenomic profiling. Our advanced computational approaches help map the progression of progenitor cells into their terminal states, revealing key regulatory genes and signaling pathways involved. By leveraging these insights, researchers can identify novel drug targets, develop regenerative medicine strategies, and improve disease modeling for more effective treatments.